Breast cancer and brain mets

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Brain metastases are the most common central nervous system tumors in adults, and incidence of brain metastases is increasing due to both improved diagnostic techniques e. Outcomes of patients remain disappointing and treatment options are limited, usually involving multimodality approaches. Brain metastases represent an unmet medical need in solid tumor care, especially in breast cancer, where brain metastases are frequent and result in impaired quality of life and death.

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The development of brain metastasis BM of breast cancer is usually a late event with deleterious effect on the prognosis. Treatment options for intracerebral seeding of breast cancer are limited and, so far, nonspecific. Molecular detailing of subsequent events of penetration, seeding, and outgrowth in brain is highly relevant for developing therapeutic strategies to treat, or prevent, BM.

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Control of brain metastasis in metastatic or recurrent breast cancer is a major theme for cancer treatment. Promising targeted therapy for epidermal growth factor receptor EGFR gene mutation-positive lung adenocarcinoma is effective systemic treatment also for brain metastasis. On the other hand, standard treatment for BCBMs is still local treatment for brain. Systemic therapy for BCBMs may be allowed to be used to suppress disease progression after initial standard local therapy Of course, treatment modalities for brain metastasis are limited, such as local treatment with surgical treatment and radiotherapy.

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To identify the incidence, recurrence pattern and prognosis of brain metastases BM among women with metastatic triple negative breast cancer mTNBC treated consecutively at a single institution during a 7-year period. Patients with histologically confirmed mTNBC were retrospectively identified. The incidence of BM as first site of recurrence and the cumulative BM incidence were computed.

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Skip to Content. Use the menu to see other pages. This section explains the types of treatments that are the standard of care for metastatic breast cancer.

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Brain metastasis is cancer that started in another part of the body and spread to the brain. Brain metastasis is not the same as cancer that starts in the brain called primary brain cancer. Brain metastases are much more common than primary brain cancer.

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Sometimes, brain metastases are found when breast cancer is first diagnosed, but the majority of the time, brain metastases occur as a distant recurrence of an early-stage breast cancer that was treated in the past. What symptoms may occur, and what treatment options are available if your breast cancer spreads to your brain? Overall, brain metastases occur in 15 to 24 percent of women with metastatic breast cancer.

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For most, the breast cancer has already traveled to another part of the body, such as the bones, liver, or lung. The risk of cancer spread to the brain is usually highest for women with more aggressive subtypes of breast cancer, such as HER2-positive or triple-negative breast cancer. If your doctor suspects brain metastasis, he or she will order an MRI magnetic resonance imaging study of the brain, often with contrast solution. This solution is delivered intravenously and then travels into the brain, helping to make the study images clearer.

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