Use the link below to share a full-text version of this article with your friends and colleagues. Learn more. Spermatozoa obtained from two oligospermic patients and one volunteer semen donor were studied by multicolour fluorescence in situ hybridization.
Infantile autism and 47,XYY karyotype. Kim II. There is growing evidence that genetic and chromosomal factors are important in the genesis of autism spectrum disorders.
XYY syndrome is a rare chromosomal disorder that affects males. It is caused by the presence of an extra Y chromosome. Males normally have one X and one Y chromosome.
Most people have 46 chromosomes in each cell. In males, this typically includes one X chromosome and one Y chromosome XY. XYY syndrome is a genetic condition that occurs when a male has an extra copy of the Y chromosome in each of their cells XYY.
Although many males with this condition are taller than average, the chromosomal change sometimes causes no unusual physical features. Most males with 47,XYY syndrome have normal production of the male sex hormone testosterone and normal sexual development, and they are usually able to father children. Affected boys can have delayed development of motor skills such as sitting and walking or weak muscle tone hypotonia.
XYY syndrome is a genetic condition found in males only. About 1 in 1, boys have it. Other symptoms can include problems with spoken language and processing spoken words, coordination problems, weaker muscles, hand tremors, and behavioral difficulties.
In the mouse XYY males are sterile, presumably because pairing abnormalities resulting from the presence of three sex chromosomes lead to meiotic breakdown. We conclude that the sterility of XYY males is caused by a combination of the deleterious effect of two Y chromosomes, presumably acting prior to meiosis, and pairing abnormalities resulting in significant meiotic disruption. Unable to display preview.
Sex Chromosome Abnormalities. The majority of known types of chromosomal abnormalities involve sex chromosomes. In frequency of occurrence, they are only slightly less common than autosomal abnormalities.
XYY syndrome is a genetic condition in which a male has an extra Y chromosome. The condition is generally not inherited from a person's parents but rather occurs as a result of a random event during sperm cell development. Treatment may include speech therapy or extra help with schoolwork. Prenatal testosterone levels are normal in 47,XYY males.